N. P. Shankley: search on Z-Library

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1

Pyrazole CCK1 receptor antagonists. Part 2: SAR studies by solid-phase library synthesis and determination of Free–Wilson additivity

Clark Sehon, Kelly McClure, Michael Hack, Magda Morton, Laurent Gomez, Lina Li, Terrance D. Barrett, Nigel Shankley, J. Guy Breitenbucher

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 209 KB

english, 2006

2

An operational model of pharmacological agonism: the effect of E/[A] curve shape on agonist dissociation constant estimation

JW Black, P Leff, NP Shankley, J. Wood

Journal:

British Journal of Pharmacology

Year:

2010

Language:

english

File:

PDF, 963 KB

english, 2010

3

ChemInform Abstract: From Histamine to Imidazolylalkyl-sulfonamides: The Design of a Novel Series of Histamine H3-Receptor Antagonists.

Matthew J. Tozer, Elaine A. Harper, S. Barret Kalindjian, Michael J. Pether, Nigel P. Shankley, Gillian F. Watt

Journal:

Year:

1999

File:

PDF, 34 KB

1999

4

ChemInform Abstract: Design, Synthesis, and Structure—Activity Relationships of Novel Non-Imidazole Histamine H3 Receptor Antagonists.

Ian D. Linney, Ildiko M. Buck, Elaine A. Harper, S. Barret-Kalindjian, Michael J. Pether, Nigel P. Shankley, Gillian F. Watt, Paul T. Wright

Journal:

Year:

2000

File:

PDF, 35 KB

2000

5

Pyrazole CCK1 receptor antagonists. Part 1: Solution-phase library synthesis and determination of Free–Wilson additivity

Kelly McClure, Michael Hack, Liming Huang, Clark Sehon, Magda Morton, Lina Li, Terrance D. Barrett, Nigel Shankley, J. Guy Breitenbucher

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 305 KB

english, 2006

6

Synthesis and solid-phase purification of anthranilic sulfonamides as CCK-2 ligands

Craig R. Woods, Michael D. Hack, Brett D. Allison, Victor K. Phuong, Mark D. Rosen, Magda F. Morton, Clodagh E. Prendergast, Terrance D. Barrett, Nigel P. Shankley, Michael H. Rabinowitz

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 156 KB

english, 2007

7

SAR studies of 1,5-diarylpyrazole-based CCK1 receptor antagonists

Laurent Gomez, Michael D. Hack, Kelly McClure, Clark Sehon, Liming Huang, Magda Morton, Lina Li, Terrance D. Barrett, Nigel Shankley, J. Guy Breitenbucher

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 292 KB

english, 2007

8

Anthranilic sulfonamide CCK1/CCK2 dual receptor antagonists II: Tuning of receptor selectivity and in vivo efficacy

Marna Pippel, Kristen Boyce, Hariharan Venkatesan, Victor K. Phuong, Wen Yan, Terrance D. Barrett, Guy Lagaud, Lina Li, Magda F. Morton, Clodagh Prendergast, Xiaodong Wu, Nigel P. Shankley, Michael H.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 253 KB

english, 2009

9

Anthranilic sulfonamide CCK1/CCK2 dual receptor antagonists I: Discovery of CCKR1 selectivity in a previously CCKR2-selective lead series

Marna Pippel, Brett D. Allison, Victor K. Phuong, Lina Li, Magda F. Morton, Clodagh Prendergast, Xiaodong Wu, Nigel P. Shankley, Michael H. Rabinowitz

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 241 KB

english, 2009

10

From histamine to imidazolylalkyl-sulfonamides: The design of a novel series of histamine H3-receptor antagonists

Matthew J. Tozer, Elaine A. Harper, S.Barret Kalindjian, Michael J. Pether, Nigel P. Shankley, Gillian F. Watt

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 337 KB

english, 1999

11

Analysis of the action of idazoxan calls into question the reliability of the rat isolated small mesenteric artery assay as a predictor for α1-adrenoceptor-mediated pressor activity

Pieter H. Graaf, Nigel P. Shankley, James W. Black

Journal:

Naunyn-Schmiedeberg's Archives of Pharmacology

Year:

1996

Language:

english

File:

PDF, 402 KB

english, 1996

12

Effect of BW443C81, a novel opioid, on non-cholinergic bronchoconstrictor responses and neurogenic plasma extravasation in the guinea pig

C. E. Shankley, C. W. P. Anderson, J. J. Adcock

Journal:

Inflammation Research

Year:

1992

Language:

english

File:

PDF, 614 KB

english, 1992

13

Unexpected relationship between plasma protein binding and the pharmacodynamics of 2-NAP, a CCK1-receptor antagonist

V. P. Gerskowitch, J. Hodge, R. A. D. Hull, N. P. Shankley, S. B. Kalindjian, J. McEwen, J. W. Black

Journal:

British Journal of Clinical Pharmacology

Year:

2007

Language:

english

File:

PDF, 156 KB

english, 2007

14

Preface and Introduction

P. P. A. HUMPHREY, P. LEFF, N. SHANKLEY, D. G. TRIST

Journal:

Annals of the New York Academy of Sciences

Year:

1997

Language:

english

File:

PDF, 135 KB

english, 1997

15

Inverse agonists exposed

Black, J. W., Shankley, N. P.

Journal:

Year:

1995

File:

PDF, 290 KB

1995

16

Role of CCK and potential utility of CCK1 receptor antagonism in the treatment of pancreatitis induced by biliary tract obstruction

T D Barrett, W Yan, J M Freedman, G J Lagaud, J G Breitenbucher, N P Shankley

Journal:

British Journal of Pharmacology

Year:

2008

Language:

english

File:

PDF, 181 KB

english, 2008

17

Goal-driven drug discovery: getting the chemistry right

Shankley, Nigel

Journal:

Nature Reviews Drug Discovery

Year:

2002

Language:

english

File:

PDF, 84 KB

english, 2002

18

Pharmacological analysis of the activity of the adenosine uptake inhibitor, dipyridamole, on the sinoatrial and atrioventricular nodes of the guinea-pig

B J Meester, N P Shankley, N J Welsh, F L Meijler, J W Black

Journal:

British Journal of Pharmacology

Year:

1998

Language:

english

File:

PDF, 452 KB

english, 1998

19

Pharmacological classification of adenosine receptors in the sinoatrial and atrioventricular nodes of the guinea-pig

B J Meester, N P Shankley, N J Welsh, J Wood, F L Meijler, J W Black

Journal:

British Journal of Pharmacology

Year:

1998

Language:

english

File:

PDF, 375 KB

english, 1998

20

Analysis of the behaviour of selected CCKB/gastrin receptor antagonists in radioligand binding assays performed in mouse and rat cerebral cortex

E A Harper, E P Griffin, N P Shankley, J W Black

Journal:

British Journal of Pharmacology

Year:

1999

Language:

english

File:

PDF, 223 KB

english, 1999

21

Characterization of the binding of a novel radioligand to CCKB/gastrin receptors in membranes from rat cerebral cortex

E A Harper, N P Shankley, J W Black

Journal:

British Journal of Pharmacology

Year:

1999

Language:

english

File:

PDF, 241 KB

english, 1999

22

Evidence that histamine homologues discriminate between H3-receptors in guinea-pig cerebral cortex and ileum longitudinal muscle myenteric plexus

E A Harper, N P Shankley, J W Black

Journal:

British Journal of Pharmacology

Year:

1999

Language:

english

File:

PDF, 209 KB

english, 1999

23

Characterization of the binding of [3H]-clobenpropit to histamine H3-receptors in guinea-pig cerebral cortex membranes

E A Harper, N P Shankley, J W Black

Journal:

British Journal of Pharmacology

Year:

1999

Language:

english

File:

PDF, 234 KB

english, 1999

24

Negative inotropic effects of isoprenaline on isolated left atrial assays from aged transgenic mice with cardiac over-expression of human β2-adrenoceptors

C E Prendergast, N P Shankley, J W Black

Journal:

British Journal of Pharmacology

Year:

2000

Language:

english

File:

PDF, 121 KB

english, 2000

25

An improved in vitro bioassay for the study of 5-HT4 receptors in the human isolated large intestinal circular muscle

N H Prins, N P Shankley, N J Welsh, M R Briejer, R A Lefebvre, L M A Akkermans, J A J Schuurkes

Journal:

British Journal of Pharmacology

Year:

2000

Language:

english

File:

PDF, 169 KB

english, 2000

26

Evidence that ET-1, but not ET-3 and S6b, ETA-receptor mediated contractions in isolated rat mesenteric arteries are modulated by co-activation of ETB receptors

Mikael Adner, Nigel Shankley, Lars Edvinsson

Journal:

British Journal of Pharmacology

Year:

2001

Language:

english

File:

PDF, 218 KB

english, 2001

27

Pharmacological evidence for putative CCK1 receptor heterogeneity in human colon smooth muscle

M F Morton, E A Harper, I A Tavares, N P Shankley

Journal:

British Journal of Pharmacology

Year:

2002

Language:

english

File:

PDF, 210 KB

english, 2002

28

An assay to evaluate the long-term effects of inflammatory mediators on murine airway smooth muscle: evidence that TNFα up-regulates 5-HT2A-mediated contraction

Mikael Adner, Andrew C Rose, Yaping Zhang, Karl Swärd, Mikael Benson, Rolf Uddman, Nigel P Shankley, Lars-Olaf Cardell

Journal:

British Journal of Pharmacology

Year:

2002

Language:

english

File:

PDF, 277 KB

english, 2002

29

Pharmacological comparison of the alternatively spliced short and long CCK2 receptors

M F Morton, E A Harper, I A Tavares, N P Shankley

Journal:

British Journal of Pharmacology

Year:

2003

Language:

english

File:

PDF, 222 KB

english, 2003

30

TNFα reduces tachykinin, PGE2-dependent, relaxation of the cultured mouse trachea by increasing the activity of COX-2

Ofir Bachar, Andrew C Rose, Mikael Adner, Xudong Wang, Clodagh E Prendergast, Ashley Kempf, Nigel P Shankley, Lars-Olaf Cardell

Journal:

British Journal of Pharmacology

Year:

2005

Language:

english

File:

PDF, 307 KB

english, 2005

31

Molecular cloning, expression and pharmacological characterization of the canine cholecystokinin 1 receptor

Magda Francesca Morton, Jayashree Pyati, Heng Dai, Lina Li, Veronica Moreno, Nigel Paul Shankley

Journal:

British Journal of Pharmacology

Year:

2005

Language:

english

File:

PDF, 714 KB

english, 2005

32

Species-dependent smooth muscle contraction to Neuromedin U and determination of the receptor subtypes mediating contraction using NMU1 receptor knockout mice

Clodagh E Prendergast, Magda F Morton, Katherine W Figueroa, Xiaodong Wu, Nigel P Shankley

Journal:

British Journal of Pharmacology

Year:

2006

Language:

english

File:

PDF, 255 KB

english, 2006

33

Correlation of apparent affinity values from H3-receptor binding assays with apparent affinity (pKapp) and intrinsic activity (α) from functional bioassays

E A Harper, N P Shankley, J W Black

Journal:

British Journal of Pharmacology

Year:

2007

Language:

english

File:

PDF, 268 KB

english, 2007

34

A novel, quantitative bio-assay for cholecystokinin type-1 receptor activity in the anaesthetised rat

Jamie M. Freedman, Terrance D. Barrett, Nigel P. Shankley

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2006

Language:

english

File:

PDF, 263 KB

english, 2006

35

Pharmacological analysis of the interaction between purinoceptor agonists and antagonists in the guinea-pig taenia caecum

D.J. Prentice, N.P. Shankley, J.W. Black

Journal:

British Journal of Pharmacology

Year:

1995

Language:

english

File:

PDF, 1.41 MB

english, 1995

36

Exposure and characterization of the action of noradrenaline at dopamine receptors mediating endothelium-independent relaxation of rat isolated small mesenteric arteries

Pieter H. Van der Graaf, Pramod R. Saxena, Nigel P. Shankley, James W. Black

Journal:

British Journal of Pharmacology

Year:

1995

Language:

english

File:

PDF, 1.22 MB

english, 1995

37

Application of a model to explore interspecies differences in acetylcholine M-receptor-stimulated gastric acid secretion

Nicola J. Welsh, Nigel P. Shankley, James W. Black

Journal:

British Journal of Pharmacology

Year:

1995

Language:

english

File:

PDF, 1.53 MB

english, 1995

38

Analysis of the activity of α1-adrenoceptor antagonists in rat aorta

Pieter H. Van der Graaf, Nigel P. Shankley, James W. Black

Journal:

British Journal of Pharmacology

Year:

1996

Language:

english

File:

PDF, 2.25 MB

english, 1996

39

Analysis of the effects of α1-adrenoceptor antagonists on noradrenaline-mediated contraction of rat small mesenteric artery

Pieter H. Van der Graaf, Nigel P. Shankley, James W. Black

Journal:

British Journal of Pharmacology

Year:

1996

Language:

english

File:

PDF, 1.79 MB

english, 1996

40

Analysis of variation in L-365,260 competition curves in radioligand binding assays

E.A. Harper, S.P. Roberts, N.P. Shankley, J.W. Black

Journal:

British Journal of Pharmacology

Year:

1996

Language:

english

File:

PDF, 1.89 MB

english, 1996

41

Analysis of the variation in the action of L-365,260 at CCKB/gastrin receptors in rat, guinea-pig and mouse isolated gastric tissue assays

S.P. Roberts, E.A. Harper, G.F. Watt, V.P. Gerskowitch, R.A.D. Hull, N.P. Shankley, J.W. Black

Journal:

British Journal of Pharmacology

Year:

1996

Language:

english

File:

PDF, 2.13 MB

english, 1996

42

Pharmacological analysis of the CCKB/gastrin receptors mediating pentagastrin-stimulated gastric acid secretion in the isolated stomach of the immature rat

David M. Hills, V. Paul Gerskowitch, Sonia P. Roberts, Nicola J. Welsh, Nigel P. Shankley, James W. Black

Journal:

British Journal of Pharmacology

Year:

1996

Language:

english

File:

PDF, 1.86 MB

english, 1996

43

The cholecystokinin CCK2 receptor antagonist, JNJ-26070109, inhibits gastric acid secretion and prevents omeprazole-induced acid rebound in the rat

TD Barrett, G Lagaud, P Wagaman, JM Freedman, W Yan, L Andries, MC Rizzolio, MF Morton, NP Shankley

Journal:

British Journal of Pharmacology

Year:

2012

Language:

english

File:

PDF, 1.04 MB

english, 2012

44

Additional evidence for differences in alpha1-adrenoceptors between rat and guinea-pig aorta

R.A.D. Hull, V.P. Gerskowitch, P.J. Martin, N.P. Shankley., J.W. Black

Journal:

European Journal of Pharmacology

Year:

1990

Language:

english

File:

PDF, 190 KB

english, 1990

45

Analysis of agonist interactions on isolated stomach assays

N.J. Welsh, N.P. Shankley, J.W. Black

Journal:

European Journal of Pharmacology

Year:

1990

Language:

english

File:

PDF, 101 KB

english, 1990

46

Analysis off the interaction between cholecystokinin-receptor antagonists on the guinea-pig gallbladder assay

L. Bishop, V.P. Gerskowitch, R.A.D. Hull, N.P. Shankley, J.W. Black

Journal:

European Journal of Pharmacology

Year:

1990

Language:

english

File:

PDF, 220 KB

english, 1990

47

RETRACTED: Obestatin reduces food intake and suppresses body weight gain in rodents

Guy J. Lagaud, Andy Young, Auzon Acena, Magda F. Morton, Terrance D. Barrett, Nigel P. Shankley

Journal:

Biochemical and Biophysical Research Communications

Year:

2007

Language:

english

File:

PDF, 387 KB

english, 2007

48

Retracted notice to: “Obestatin reduces food intake and suppresses body weight gain in rodents” [Biochem. Biophys. Res. Commun. 357(1) (2007) 264–269]

Guy J. Lagaud, Andy Young, Auzon Acena, Magda F. Morton, Terrance D. Barrett, Nigel P. Shankley

Journal:

Biochemical and Biophysical Research Communications

Year:

2009

Language:

english

File:

PDF, 111 KB

english, 2009

49

Pharmacological analysis of CCK2 receptors up-regulated using engineered transcription factors

Magda F. Morton, Pei-Qi Liu, Andreas Reik, Ragan de la Rosa, Matthew Mendel, Xiao-Yong Li, Casey Case, Carl Pabo, Veronica Moreno, Jayashree Pyati, Nigel P. Shankley

Journal:

Regulatory Peptides

Year:

2005

Language:

english

File:

PDF, 141 KB

english, 2005

50

Neuromedin U stimulates contraction of human long saphenous vein and gastrointestinal smooth muscle in vitro

Neil A. Jones, Magda F. Morton, Clodagh E. Prendergast, Garth L. Powell, Nigel P. Shankley, Simon J. Hollingsworth

Journal:

Regulatory Peptides

Year:

2006

Language:

english

File:

PDF, 331 KB

english, 2006